arachidonic acid cascade and related medications
the improved version – clearer and slightly more concise compared to the previous. I’ll be talking slowly, recommended to speed up 1.5x 日本語訳有ります！
hello everyone. today i'll be talking about arachidonic acid cascade and related medication.
the learning outcome for this presentation is that you'll be able to learn about the arachidonic cascade –
which is the target of many drugs that are very
commonly used, as well as (something that) we are very familiar with,
and these are easily understood using this diagram.
arachidonic acid comes from the cell membrane.
so you can see the phospholipid bilayer, and…
membrane phospholipid basically means its a component of cell membrane
so we have this membrane phospholipid turning into arachidonic acid – with the help of
from there, it can go onto two types of products, which are;
prostaglandin A2 with the help of cycloxygenase,
with the help of 5-Lipoxygenese
I like to call it (the left side) the leukotrine pathway, and the (on the right side) prostaglandin pathway
we will be looking at the prostaglandin pathway first
so after Arachidonic Acid has been turned into Prostaglandin A2
It rapidly changes into Prostaglandin H2 because A2 is pretty unstable.
from there, PGH2 can change into many different prostaglandins
which (of them) are illustrated here.
so… Prostaglandin I2, Prostaglandin D2, Prostaglandin E2, and Thromboxane A2.
lets look at what they do, briely, one by one.