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– Can you explain the cause
of physiological insulin resistance?
– Hey, it's a million dollar question.
I wish I could explain the exact cause
of insulin resistance,
but unfortunately no one
can say for sure.
Of course there are many
things that we do know,
although the exact process and timeline
of the development of insulin
resistance is still uncertain.
What are things that we know?
Genetics play a role in this, mmkay?
Genetics play a role in this,
and even more concerning,
probably something called
epigenetics plays a role in this.
And that means that we have
genes, maybe possibly all of us,
have the genes to develop
insulin resistance,
but those genes get
turned on in some people,
but not in everyone.
And factors such as
what was the environment
when a mother was pregnant
probably play a big role in this.
So again, genetics
definitely a big factor.
Number two on this is
what you were exposed
to as a child as well.
So in other words it's very interesting,
but beta cells of the pancreas,
which are the cells which produce insulin,
are a lot like the cells of the brain,
meaning that they develop
a lot when we are younger
and then they stop developing.
We're not growing new beta cells,
just like we're not
growing new brain cells
when someone is older.
That's all happening in childhood.
And if in childhood someone
is exposed to a lot of sugar,
processed carbohydrates young in life,
what can happen to those beta cells
is that they can hypertrophy,
meaning they get bigger.
And if your beta cells are bigger,
even later in life, if you eat
the exact same carbohydrates
as someone who didn't have this problem,
who has normal beta cell size,
you're gonna throw out more insulin.
And so again, the higher
levels of insulin around
actually themselves, it
is thought, are the key
to creating that insulin resistance.
Of course, again, with
genetics playing a role.
So genetics, early childhood
exposure probably play
a big role, and again
diet in early childhood
is a big deal there.
But again, even if you didn't
have childhood exposures,
if you're eating a lot
of refined carbohydrates,
and once again increasing
the insulin in general,
that high level of insulin itself
can be toxic to the beta cells.
So it's probably not one of those answers,
it's probably a combination.
But again, once you have
it, what can you do,
decrease and deal with the cause of it,
not trying to bandaid
it just with medication.
Deal with the insulin resistance
by allowing your body
to need less insulin.
– Yeah, the million dollar question.

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