Dr Jim Daily III discusses the Microbiome Today we’re talking about the microbiome all those little gut bacteria and other things. They’re not all bacteria but these …
Hello everyone I'm Dr. Jim Daily
from Daily manufacturing and bringing
another training seminar to you today
today we're talking about the microbiome
all those little gut bacteria and and
other things actually they're not all
bacteria but these things that live
inside of your gut that have a really
major impact on your health and on your
metabolism now this is something we will
probably talk about off and on for the
next few years at least and maybe you
know on and on because we're finding out
more and more that almost every system
in our body is affected by the
microbiome we have always heard this
thing that death begins in the colon
well that's becoming more and more
evident as we go along so many things
are affected by the microbiome that it's
becoming one of the really hottest areas
of research today the most important
journals in the world like science and
nature are publishing articles on the
microbiome almost every month so that
shows you the kind of interest in the
microbiome the kind of money that's been
really poured into studying the
microbiome and there's still a huge
amount we don't know about it so it's a
really wonderful area to be in right now
and I'm really hoping to sort of get you
started on understanding it today that's
the main goal of today's lecture is to
help you be able to read and understand
what's being published they will talk
about some other things too but that's
the one thing that I really hope I can
help you with today is to be able to
pick up a magazine see an article on the
microbiome read it and get something out
of it because
the terminology is very different from
what we are usually used to now the
human gut is really quite phenomenal it
starts with the mouth and ends at the
anus where everything comes out and in
many ways you could think of the gut as
being the outside part of the body still
because it's sort of like a hollow tube
that runs all the way through like you
know from the beginning to the end and
the purpose of the intestinal tract is
to limit what can get into the rest of
the body and to help bring in the things
that it needs so it's really very
selective about what it lets cross into
the bloodstream and the rest of the body
but it's really very active at grabbing
what it comes through there that it
needs now some of these things that the
gut needs are really not easily absorbed
and sometimes the microbiome itself can
make these things more easily absorbed
it can also make them more active so
there's a lot going on there besides
just digesting food which we usually
think about now this digestive tract is
about 30 feet long if you stretched it
all out and there's different I've seen
some puzzle looks there but really is it
folds all around in there
it has each area is really specialized
for instance the mouth desert chewing
the gut esophagus works the food down
into the stomach the stomach kind of
squeezes and grinds and gives us an acid
bath begins the digestion in the small
intestine you've got enzymes being
released to help break down proteins and
other food particles and
molecules the large intestine they used
to think it didn't do anything but just
sort of absorb water and get rid of
stuff but they finding that's not really
true anymore
and although there's bacteria all the
way from the stomach to the well the
whole digestive system has bacteria
actually from the mouth all the way to
the end but the gut has the large
intestine has the biggest volume by far
of bacteria and other microorganisms and
it is there that a lot really takes
place we find now that many molecules
are absorbed the bacteria in the colon
can make small molecule such as butyrate
and acetate and these are absorbed and
infect the body they can make other
small molecules they could even make
neurotransmitters that affect the brain
signaling mechanisms that can affect how
we eat or don't eat and it's amazing the
things that actually come out of the
colon and there it's orbiting the rest
of the body but a lot of those are
actually made by those bacteria that are
there so you can see that we have a very
very intricate and very well-planned
system of dealing with foods throughout
the intestinal tract well we'll get into
a little bit of terminology first here
of course I think most people are
familiar with the term probiotic it's a
beneficial micro organism usually
bacteria and yeast but other things have
the potential of being probiotics as
well
bacteria are certainly the most commonly
sold commercial probiotics prebiotics
are food substances that the bacteria
you digest and used to make these other
molecules
to grow for their own energy and to
actually they stimulate the
proliferation and of those bacteria what
the prebiotic foods that we eat really
into a large extent determine what the
bacteria in our digestive tract are so
then we have sin biotics symbiotic are a
combination of probiotics and prebiotics
so you're putting in the bacteria but
also you're giving the food to go with
the bacteria so that has a symbiotic
relationship so that's what we refer to
as symbiotic
now there's another term that's not
really accepted yet too much and that is
post biotic it has appeared in the
literature some actually I kind of like
that term because it's something that
expresses it pretty well it's when you
kill a bacteria you'd think that it
could no longer do anything but that's
not exactly true
there have been a number of studies now
feeding killed bacteria to people and
the molecules the the bioactive
compounds that are made by those
bacteria are still there and so you
don't have the live bacteria but you
still get these substances that were
made by those bacteria in a concentrated
form and that's a what they're referring
to as a post biotic and that can have
pretty profound effects sometimes and in
the journal scientific journal I edit a
journal medicinal food we've had several
papers appear using what we call post
biotics so we find that they really do
have an effect on the body now you'll
hear a lot of times about gram positive
and gram negative bacteria
this doesn't really have too much to do
with functionality of the bacteria it's
just a way that microbiologists used to
kind of categorize bacteria when they're
trying to figure out what they are well
you know there's certain bacteria
grandpas even certain or grand
so that's one of the first things you
might do in trying to identify a
bacteria is determining where this grand
positive gram negative and you know
you've lost you know you eliminated
about half of them whichever way it is
the gram positive has proteoglycans in
the cell wall of the bacteria that will
absorb and retain the crystal violet dye
that they put with it the grand negative
don't so when you look at gram positive
under a microscope that has been stained
those bacteria looked colorful when you
look at the gram negative bacteria
you'll want a colored background because
they're going to look kind of clear and
you they won't show up unless you've got
a background that they can show up
against
so you color in it that's a sort of
starting point but a lot of times when
you read the literature they'll talk
about gram positive gram negative don't
worry too much about that that part
isn't really important to you as a
consumer that's it helps these guys
identify them we have different kinds of
organisms we talk about symbiosis that's
two organisms that actually benefit you
might maybe like to write back sillas I
said Alice benefits us and we benefited
by a gift
eating food that it can eat so it's a
symbiotic symbiotic relationship there
we give it food and it turns around and
makes new things out of the food and
gives us food back so actually this
happens it turns out that if you get a
germ-free Mouse they actually make these
for research models they take mice
before they're born surgically remove
them put them in a sterile environment
if they need to they give them
antibiotics they're completely germ-free
now they can still live without the
bacteria that doesn't kill the mice they
want you know them or us will not be
quite as healthy without the bacteria in
there in fact we'll have a lot of health
problems without it but we won't be just
outright killed by it like if they
removed our livers for instance however
the
germ-free mice I actually have to eat
about 30% more than other mice because a
lot of these foods they eat contains
some foods that can't be the energy
can't be digested and distracted from
them without the help of the bacteria so
that shows that the bacteria is actually
pretty important for getting the the
calories out of food even so it's really
important we don't have germ-free people
very often there have been a few cases
of that but not enough to study in that
sort of way then we have communal
commensalism that's where the two
organisms kind of live together put up
with each other but they don't really
benefit one another much they just
they're far as anybody can tell that
would be commensalism then we have a fib
iosys and that's actually probably where
a lot of these bacteria fall into this
is where a bacteria might benefit a
human and vice versa under some
conditions under under other conditions
well it they might be harmful to each
other so it would depend on the
situation probably in most cases the
situation where it would be harmful is
where you get too much of it growing so
you have an overgrowth of a bacteria at
the expense of other bacteria and that
could cause problems so that would be
the major way that would work most of
the time on the other hand most of the
time with these bacteria they're in
pretty good balance so it works out to
almost a more of a symbiotic
relationship but if it gets out of
balance then you've got problems it's
not quite symbiotic under all conditions
now
last uh about a year and a half ago
experimental biology meeting in Chicago
I had listened to a really interesting
talk by a professor who did some
research on African Americans and
matched counterparts in a rural area of
South Africa basically what they found
out was that African Americans get a lot
of colon cancers and actually colon
cancer is a second most deadly cancer
anyway but African Americans are
especially at risk for colon cancer
however what they found out that the
same people the same heritage from South
Africa had almost no colon cancer it
didn't exist in that population
now they had other health problems for
sure but they did not get colon cancer
and they were genetically the same I
mean it only takes one generation the
first generation to come to the United
States or another Western country
usually ends up with almost the same
risk and second generation does for sure
so it's not a genetic thing snakes don't
change that quickly so they figured it
must be something to do with diet and so
what they did was kind of interesting
they took food from South Africa brought
it to the US to feed those people
exclusively in the US who were the
matched counterparts of the Africans
they took us food lots and lots of meat
and other things to Africa and gave them
the Western food and it was very heavy
on you know steak and roasts and things
like that well it turned out what they
were measuring were colon polyps which
are precursors to cancer cells and they
can pop up pretty quickly so
didn't have to take a long time to get
the results and actually the African
people switched to the diet American
diet started developing polyps and the
precursors to colon cancer almost
immediately the matched controls in the
United States they started shrinking
call other colon cancerous precursors
and they're got they did the in
endoscopes up to look at the colon so
they can see very profoundly that they
reverse the colon cancer risk in the two
populations now they couldn't carry that
on you can't go to Africa and give
people colon cancer that's not
permissible however it's a sad
commentary that you know feeding them
our food would give them colon cancer
and be something you wouldn't want to do
to them so we have to think twice when
we have programs to take food to people
what we're feeding him are we really
doing them any good or we are harming
them
but what the when they switch the the
people in Africa ate primarily a ground
corn mush a whole corn all the corn bran
and fiber was in it and that was a
staple of their diet aids a little bit
of meat but not much they couldn't
afford it
now when they brought a meat to eat they
loved it you know they're not
vegetarians by choice they're
vegetarians because they can't afford
meat and you know they really dug into
it but you know the fiber switch went in
the Americans from 14 grams per day to
55 grams per day a huge difference in
fiber the fats which went from 35
percent of calories from fat to 16
percent so they really increase the
fiber hugely and decrease the fat to
about to less than half of what they
were eating before so it really was
major dietary
change so we can see that this had a
really profound impact on colon cancer
risk you know another thing that we're
starting to look at a lot is
inflammatory bowel diseases what we
didn't realize until a meeting in Boston
I didn't realize how a meeting in Boston
just a couple months ago is that before
1960 there was almost no inflammatory
bowel disease in the United States you
can see a big map of it and just one
little tiny place in southeastern United
States down Georgie I think had any
colon cancer on there and just a few
little places scattered around just tiny
little spots on the map and then you
could see the map they had today and it
was all over it so this is a disease
that has really come to the forefront in
very in most of our lifetimes you know
and you can see the trend this is only
going back to 1990 and the incidence of
inflammatory bowel disease ulcerative
colitis which is one of them and Crohn's
disease which is the other one and
they're really taking off now we don't
know can't say for sure what the cause
is
however it might be attributable to
antibiotics overuse of antibiotics has
really been doing a number on our colon
and other bacteria in the gut and it's
really starting to look like you know on
the timeline you can say well these were
the kind of the first generation of
children that we're getting antibiotics
my age when I was young you know
penicillin was the new wonder drug that
had just come out so you know this was
affecting people right after the
advent of antibiotics that's not to say
you shouldn't have antibiotics you know
when you need them they're lifesavers no
question about it you can really save a
person's life with them so I'm not
telling you don't use antibiotics I'm
saying that you might want to think
about whether you really do need the
antibiotics here for don't you know
beg your doctor to give you an
antibiotic just because you think it
might make you feel better you know make
sure it really will work another thing
that we found is that anybody likes
really affect h pylori and that's
something that's been used a lot lately
because we know everybody knows that
Helio bacter pylori is what causes most
if not all of the stomach ulcers so
we've decided that h pylori is a bad
bacteria that we need to get rid of and
the only place that lives is in the
human stomach so it has to be
transmitted from person to person other
animals don't have it I never found it
anywhere else except in human stomachs
so we get it from each other and some
people don't have it at all however in
this book that I highly recommend I
don't know if I agree with everything he
says but missing microbes by Martin
Blaser really goes into this quite a bit
and he's a medical doctor a
gastroenterologist who worked for the
sinners is for Disease Control has
worked after that at Vanderbilt
University I think he's now at the Penn
State or the University of Pennsylvania
one of those but very well-respected
however he observed that when he got
stomach ulcers
he took a course of antibiotics and then
they measured the date of stomach tube
to get the samples out and
that all of his HT pylori had been
killed off though he didn't have any
more sure enough the stomach ulcers went
away but within a few months he
developed acid reflux and he wondered if
there was some connection there and he
had been a major researcher on h pylori
and using antibody see it read but he
was not an anti antibiotic at that point
but it got to him to think you know
what's going on here what's the
connection and he started doing some
research on it actually as it turns out
people with acid reflux are twice as
likely to not have h pylori i in their
stomach it appears that it is actually
protective against some of the stomach
problems you have this is one of those
bacteria that we were talking about
where that can be good and it can be bad
apparently h pylori if it's at low
levels it doesn't bother you in stone
most people have h pylori in their
stomach and don't have ulcers
you know however when you get it out of
balance with other bacteria or other
things or you do something that causes
it that you know suddenly it explode
literally in your stomach and you're
filled up with it then it becomes bad
and so you may not necessarily want to
just get rid of all of it although it's
hard to sort of gauge antibiotics where
you get down to a certain level right
now because it's it's a bit invasive to
test for what's in your stomach but you
know it's not necessarily something you
want to always get rid of sometimes
you'll need to now where did we get our
bacteria from to start with and I think
a lot of us have heard the story at
birth we have very little bacteria our
intestinal tract looks like a desert
some people are debating now whether it
really is totally
sterile or not they some people are
thinking that maybe there are some
bacteria there that are in there in the
uterus even before and in the with the
babies even before they're born but most
of the bacteria that a very young
infants has they gain coming through the
birth canal so they pick it up as they
come through from the mother and then we
have a lot of people doing c-sections
there are some countries in the world
today where 70% of the bursar by
c-section doctors just don't you know
want to do it any other way and it ends
up being an economic issue a lot of
times the doctors get paid more for
c-sections than they do for waiting
around for the baby to come so they
spend less time and they get paid more
because it's a surgical procedure so you
know here we have a situation where the
economics of the medical profession can
get us off to a bad start as infants
because they don't get the bacteria
right off the bat
that they need now it doesn't take long
for starting to build up the influence
after they've been around just a short
time you know instead of a dad's that
we're beginning to see a bit of a
village with some life in it so they're
getting that from their mother first of
all breast feeding you get the baby gets
bacteria it also gets some Cree biotics
there are special sugars in the mother's
milk about 17% of the sugar actually the
energy there doesn't even get digested
directly by the baby it goes strictly to
gut bacteria
so those prebiotics are very important
to in the breast milk so we see that you
know if they're especially if they're
getting a natural birth and
breastfeeding the babies are starting to
populate
of course by the time you get to
preschool you'll have almost adult
bacterial population and that looks like
a city in your gut then all kinds of
life and you know there are actually
more cells in your gut than there are
human cells and the whole rest of our
body so you know it's it's a very just
billions and billions of them trillions
actually so lots of them but then what
happens as we progress a little bit
along the preschooler gets in here
infection and goes to the doctor and
gets an antibiotic well that's just like
you know atomic bomb a nuclear weapon to
the bacteria it can go out and just
wreak havoc with your gut bacteria it
always does actually and suddenly we're
back here again you know almost like a
desert there in some cases it actually
doesn't get quite that bad it's probably
more like the little village but you
know it can go through and just really
wreak a lot of the gut bacteria so
antibiotics are treatments that are
necessary to save life very often but
they are also treatments that can cause
a lot of health problems in the book I
just showed you by Martin Blaser the
missing microbes he goes into a lot of
detail in studies and you really it's an
interesting book to read I highly
recommend it it's missing microbes very
simple title you can find it on Amazon
easily but he talks about how
antibiotics in early childhood can
affect your risk for obesity it can lead
to possibly autism I mean and there's
studies to back him up it can lead to
later in life it can lead to asthma it
can lead to a lot of things and these
are just a few that he's come up with
our and colleagues that he's worked with
so I really put out a lot of cautions
here on ahead of biotics I don't want
people to not use them if they need them
because that's important and you can get
back some of those gut bacteria it's not
necessarily a death sentence for you
whole microbiome to get them but if you
keep getting them it's gonna be pretty
close so now what we see here is that
bacteria can really grow rapidly and
this is a log scale just show an
explosive rows of bacteria and some of
these can double every 15 or 20 minutes
and so as you're doing that you can see
that you know just in a day's time you
can go from just a handful of bacteria
to you know almost being overrun by them
and then at some point the bacteria
reaches stage where they are
self-limiting and I'll give you well
acidophilus the lactobacilli acts
Adolphus is one you put these bacteria
and some others into yogurt for instance
so they grow really rapidly there's just
a little bit of starter in the yogurt
culture and in two three days you've got
that thing just totally congealed with
the bacteria and the lactic acids and
all the things that are in it well the
lactic acid drops the pH down and that
causes the bacteria to quit growing it
gets below their threshold of of comfort
so they're self-limiting in that yogurt
culture they don't just keep growing and
growing and growing
the lactic acid prevents that and
there's other things that can prevent
growth so you can see a stationary phase
and then sometimes they'll drop off h
pylori happens to be one of those that
can dribble and it's numbers and and
just something like 15 minutes very
quickly so some of these things are
bacteria that we have to be very careful
with another one that does it's kind of
that way too is a really interesting
bacteria they talked about in the
meeting a year and half ago quite a lot
as a Comanche I mean it's a filler it's
not a bit
yet as a probiotic supplement I don't
think it could be at some point however
it's one of those that you have to be
careful with it can be very good it's
one that's been studied a lot for
preventing obesity what it does the
Ackermann SIA uses the mucin in the gut
lining and helps break it down and so
that makes it possible for more musing
and to keep it turning over if it
doesn't break it down you get a lot of
you know sludging and not-so-good stuff
accumulating in the gut so you've got to
get the mucin that lines the gut
digested and removed and new produced
and so you run into the gut problems if
you don't have enough of that however it
turns out that in people with these
inflammatory bowel diseases they
actually have too much a cure Mencia a
lot of times that's digesting the mucin
before it can be replaced and so it
can't be replaced fast enough is eating
it up too faster than it can be made by
the gut lining so then you run into
another problem so that's just an
example of how a bacteria can be both
good and bad and it's really up to you
know determined by how fast it grows
what's supporting the growth and how
much is there and we'll talk a little
bit about taxonomy in just a minute and
this is just a basic tree of life so to
speak with the life at the top a little
different than you may have learned in
school they've changed all that Tech's
elements like to change things a lot but
you know we used to think about the
animal kingdom the plant kingdom the
mineral kingdom that kind of thing we
don't do that anymore but let's just go
on past that for a minute and go to a
much more complicated slide but and this
is really telling us where we are and
this is
a slide that I really have worked a lot
on I think I hope it will help you kind
of understand where everything fits in
is a little niche up here we talked
about the taxonomy of life and that's
all life forms period and that's at the
top of the chain and then we have three
subcategories called domains and instead
of the three kingdoms so we used to have
we'd have three domains of life we have
the archaea and that's up here but I
didn't do that right
okay I'll forget that okay I was going
to try Circle it on here now practice
that later but the archaea up here are
what's considered the most primitive of
the species the bacteria pretty
primitive also and then we have Eukarya
which were part of that one and that's
animals plants fungi Protista all three
of these categories are found in the gut
now the okay and Jonathan got that fixed
for me so you see up here with the
archaea that this is a actually one of
my favorite categories of life-forms
because it's the one we know the least
about if that makes any sense it
probably doesn't to you but it's really
an interesting life form and this is the
one that you've probably heard of and a
lot of people are still calling bacteria
but they're not they're actually culture
to the eukaryotes and they are Eukarya
then and us then it our to the bacteria
genetically but these are found in a lot
of different places a lot of them over
what they call extremophiles you find
them in the hot vents and boiling mud
pits in Yosemite and Yellowstone
National Park the thermal vents in the
ocean which are highly acidic with
sulfuric acid and
boiling temperatures have these
life-forms there these are the ones that
can actually eat plastic and a lot of
people thought that plastic relief
forever and it does last a long time
this isn't a fast process eating the
plastic isn't but it will happen with
enough time it may be hundreds of years
or thousands years for the Archaea get
around to it
but it will happen they can digest it
also archaea can eat petroleum from oil
spills and they find it living in it
where you think nothing could live so
these are really interesting life-forms
that are found also in our guts now we
don't know much about them they're not
available it's probiotic supplements yet
although some people are saying it's
coming but these are very interesting
group that we don't understand a lot
about and that's one of the things I
like about the microbiome there's so
much there that we don't know it's a
wider room for research but I'm really
thinking that these archaea
are gonna be up and coming superstars in
our microbiome but I can't tell you too
much about them yet
then Eukarya over here on the right you
can see there most of those are not in
our guts most of these a lot of the ones
you see on there have guts however with
a minute the fungi and the Protista the
some of these sayings we do have
probiotic yeasts actually so some of
those are probiotics however the major
group of probiotics that we have
available are the bacteria this up here
and the kingdom that most of just about
all of them are in the bacterial Kingdom
are the you bacteria
and when we talk about bacteria in the
gut
we usually talk most about the different
phylum or the different species and
strains and the ones in between we kind
of ignore a lot of times and it's just
mostly because it gets really
complicated but a lot of times you'll
see in this research or in articles
mentions of the aquino bacteria the
formaiities the bacteria d the
Proteobacteria are pretty common but we
don't talk about them a lot and most of
them are kind of in the category of ones
that we don't like so much although it's
kind of like h pylori maybe they may not
be that bad under the right conditions
so that's something we don't know yet
but a lot of times you'll see people
writing about the balance of from for
mickey's to bacterio teas that's
something that there's a lot of interest
in most people have more of these in
fact I'd say you know the dolt in a room
like this probably about 60% of the gut
bacteria are of this category and some
of them are very good because the
lactobacillus acidophilus if we go down
this one we'll see is in that group
however most of the time we're looking
at dietary ways of increasing this one
relative to this one
not getting rid of this one but getting
that balance up it seems like this is
the one we have the hardest time keeping
up at the phylum level so that's
something that you will want to you know
try to file away in your brain because
you will see this if you do reading
about articles about the gut bacteria
and healthy microbiomes
the formaiities to the bacteria DS
generally you want to get these up now
it's always possible that somebody might
be the only opposite side of that and
want to do the other but for most people
that's what you want to do
now as we go through the taxonomy of the
bacteria you can see down here that we
can go take Formica T's go to back C lie
down here to lactobacillus the
lactobacillus family the genus
lactobacillus we've all heard of I think
and then acidophilus lactobacillus
acidophilus that's the most common
supplement and food bacteria as far as I
know that we actually isolate and and
sell and there's good reason for that
lactobacillus acidophilus is a most
studied of all bacteria in fact it was
actually first isolated identified by
the Nobel Prize winner well he called
himself
Eli la x mission accom he's a Nobel
Prize winner kind of the father of
modern microbiology and microbiome
research he identified this el
acidophilus which is still very commonly
used today in 1890 now keep in mind that
we didn't actually discover vitamin C
till 1912 and didn't isolate it till
about 1930 and be able to actually make
it so this is something that goes way
back to very early research and is the
most one of the most studied nutrients
other than minerals that we have
probably the most studied other than
minerals that we have it's a very very
well studied gut bacteria it's usually
seen as little rods when you look at it
under the microscope and you can see
that and like most good bacteria it
probably helps by reducing inflammation
by encouraging
the t-regulatory cells that immune cells
called t-cells the category that are
called regulatory ones that are made to
suppress the immune system and keep it
under control
going wild so to speak and so it it
actually causes them to produced
interleukin 10 and so that's really one
of the ways it helps control gut
inflammation and very likely very
important for a lot of these
inflammatory bowel disease is to have a
lot of that it also is very good at
producing something here's a new word
for you maybe bacterio syns
these are substances produced by
bacteria to get rid of other bacteria
and it turns out that a lot of these
bacterias selectively get rid of some of
the ones that are not good and
acidophilus is one of them so it
actually can help kill off some of the
bad bacteria now there's a number of
well researched benefits of acidophilus
for improving blood pressure and
lowering cholesterol providing viral
bacterial and fungal infections
improvement of infant conditions gut
problems
it has nutritional benefits because it
can help make lactic acid and other
things that can benefit us nutritionally
it can reduce the severity of allergies
and helps digestive problems so it's a
very beneficial bacteria and like I say
it's very well researched now another
one that's very closely related awfulest
is the lactobacillus salivary as' I'm
mentioning something that we have right
now it's particularly good at
suppressing pathogenic bacteria it may
be a little bit too good sometimes it
may get some of the good ones so I
actually like to use this a little
differently
the acidophilus the lactobacillus L of
various
one I usually take tell people to take
when they're doing a colon cleanse
they've got some bad stuff going on it's
really good at going through and
cleaning a lot of that stuff out the bad
ones the bacteria since it produces gets
rid of a lot of the nasty stuff in there
however it's not one that hangs around a
long time and colonize this in the gut
so it's not the one that you really want
to just take all the time to keep your
good bacteria because it doesn't stay
around but it's a very good one
therapeutic Lee to do and I tell people
to use that for instance with our
miracle 7 colon cleanser a lot of times
take those two together and that really
helps get rid of a bad stuff including
bad bacteria but also some other things
that may be going on that are not so
good very good combination and then
follow it up with the acidophilus colon
aid which has acidophilus and the bifida
bacteria very very good way of kind of
getting your gut back to normal the
lactobacillus alvarius has been shown to
help people with irritable bowel
syndrome for instance by getting rid of
some of the things that are causing that
the bad bacteria
it's suppresses bacteria that can
translocate through the gut get to the
pancreas and cause pancreatic necrosis
and it's been used for that this is a
pancreatic crisis is a life-threatening
disease a very frequently fatal problem
and it's actually good for that so
something that can be a preventative
that if you have struggled with that you
might want to think about taking that
it's been shown to help atopic
dermatitis in children and like I say I
prefer to use it as a standalone
probiotic followed up by others finally
we have Bifidobacterium bifidus it's one
of the most important bacteria in the
colon those large intestine the the
acidophilus is more up in the small
intestine although it can be in the
colon
they can be in the mouth and the
esophagus it's in the vagina of women it
can get into the urinary tract of ways
it can be a lot of different places
Bifidobacterium bifidus is not quite so
robust it doesn't grow where there's
oxygen quite as well as the acidophilus
does however it is another grand
positive bacteria one of the most common
probiotics in a healthy colon however
we're finding that doesn't show up much
in the mice that we were working with
and studying their bacteria so that's
something just keep in mind mice don't
always work quite the same as people do
with probiotics so the mouse studies can
be beneficial but you know watch them
carefully it's also found in the colon
and small intestine at the very lower
part of the follow intestine to
oligosaccharides or in Ulan is a very
good food for those bacteria and it
causes it to really proliferate and I
like to really think about our
intestinal tracts as Gardens where we
plant seeds perhaps that would be the
probiotics that we put but we want them
to grow and order for them to grow
they've got to have the nutrients if
it's plant seeds if I made of seeds out
in the Mojave Desert they're probably
not going to give me any tomatoes
sometimes I'm lucky if I get them at
home but anyway that's another matter
but you know the environment isn't right
they don't have what they need to grow
in the Mojave Desert if you try to plant
them in a swamp in Florida they're not
going to grow either because they need
to you have the right thing that's not
the right environment for them so what
we have to do is create an environment
in our guts to grow the good bacteria
and that's what the African Americans in
the study I mentioned earlier were not
doing they were not giving the good
bacteria what they needed so that's why
they were getting the
colon polyps and headed toward colon
cancer the Africans were doing it they
were giving those bacteria what they
needed the fiber in that corn was
feeding the good bacteria and one of the
major ones was that a cure man see I
mentioned that you can overdo sometimes
but that was one that was doing very
well with the but not too well with the
African population so we can see that
most of the time the really limiting
factor we have with gut bacteria is not
that we didn't ever get the gut bacteria
to start with we've gotten a lot of
bacteria over the years but we didn't
give him the right environment to live
we didn't give him the right kinds of
food we didn't make them grow and so or
we killed them with antibiotics and
actually I talked to Martin Blaser about
that once and I mentioned that from what
I could tell the most important thing
was not giving people the probiotics but
from what I've been reading at the time
the more important thing was to give
them the right prebiotics and foods so
the ones that were there could flourish
and be at a normal level
he said that's probably true in a lot of
cases he says but there's a lot of
people that just don't have those around
to proliferate anymore
because of the antibodies and he
insisted that antibiotics can wipe out
the entire population entire species a
lot of times in our bodies so that's
what he told me and I went out got his
book after talking to him and read it
and I can see he's right so that was a
very interesting conversation I had
experimental biology about three years
ago in San Diego and here we find that
the bifida bacteria that we've been
talking about it also has quite a list
of things that can do you know it can
act as a immunomodulator inhibit growth
of a lot of harmful bacteria and
yeast improved mineral absorption reduce
liver toxins produced nutrients such as
folic acid can be made by those they can
lower cholesterol and triglycerides also
reduce food intolerance and restore
normal intestinal flora and I think
that's the the really big one there
because if you get intestinal flora
balanced and restored then you can start
getting it right and you know a lot of
these bacteria that are very important
in our intestinal tract we've never been
able to grow them and sell them as as
probiotics because they just simply
won't grow in a commercial culture
situation we can't grow them outside the
body and so we can't always put back
what we're missing with a probiotic
however a lot of the time maybe most of
the time there's just a tiny bit of it
left
in fact the appendix may be where a lot
of these bacteria are stored and are
protected from antibiotics and other
insults and gradually get back out and
restore if we give it the right
conditions and we give it the good
bacteria to help create the environment
for it to grow now there are some things
that we've got to be careful about with
bacterium the bifida bacteria does not
survive
stomach acid very well it's a little bit
more persnickety than acidophilus is
about where it goes now a lot more than
the else are various so what we can do
is use these delayed release caps and
that's what we use with our all of our
probiotics they don't die dissolve in
the stomach they don't dissolve until
they get past the stomach in a more
neutral environment and then they'll
release that gives you a lot more
benefit you're much more likely to get
benefit from your probiotics that way
and it happens that our two major
that we have are the : 8 in the L Salif
areas and colonnades wonderful keeping a
healthy balance of bacteria this we've
got the most important in my opinion
bacteria in L salivary is for the small
intestine and you know also elsewhere
but definitely the most important one
for the small intestine and the bifida
bacteria which is the most important one
for the colon to give for the colon so
we get the two best ones together with
fructooligosaccharides which really
helps feed those bifida bacteria in
particular and then we also have the L
cell of various which is relatively heat
stable but still it's better to
refrigerated and colon eight as much as
you can refrigerate it it's not like if
these get warm they die immediately but
you know the excess heat does over time
degrade them some so when you get them
in I would recommend go ahead and put
them in this refrigerator right away and
we keep them refrigerated here or frozen
the bacteria itself before we put it in
capsules is always frozen and we
brilliant out a little bit at a time and
make capsules all through the year so we
keep them as fresh as possible and
that's what I'm gonna finish up on today
we've got some wonderful products we're
going to be coming out with more over
the course of year at least I hope to
and still working on trying to figure
out the very best combinations to make
for everybody and for myself so with
that I'll ask if anybody has questions
or observations I'm happy to take
questions either from people over the
internet or the people's right here was
it understandable could you okay well
that's a good start
if you could understand it any questions
I don't know that I always have the
answers but I'll certainly give it a
stab
I don't hear any questions from people
here or the Internet
so with that we'll we'll stop for today
and we'll have something else for you
next month it probably won't be
probiotics next month although we'll
have it again at least a time or two
over the course of this year and it may
come up frequently during the year even
if it's not the main topic because this
is a topic that really impacts almost
everything in our body it's amazing so I
hope you all will use this to sort of
get started and start learning for
yourself more about it and you know
always glad to hear from you if you read
an interesting article like to know
about it the probably the most important
thing you can do however is to really go
to primarily a plant-based diet
with lots of fiber that will really do
wonders for your gut bacteria and will
help every aspect of your health and
thank you very much

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