This video introduces Non-invasive Micro-test Technology (NMT). It explains how NMT helps scientists reveal the physiological functions linked to the genes and …
Hello everyone, as you may have noticed
we are entering the post genomic era
and scientists are increasingly more interested in
linking
physiological functions to genes and proteins.
As a result, scientists are in desperate need of a
technology
that can help them reveal these physiological
functions.
Today I'll introduce to you a technology
that does just that.
It is called Non-invasive Micro-test Technology,
also known as NMT.
NMT is an integrated system,
designed to detect specific and/or selective,
ionic and molecular activities, in extracelluar space.
The following ions and molecules
are currently available to scientists.

But what is this technology about?

In Massachusetts in the early 1990s,
Dr. Lionel Jaffe along with his associates
introduced the concept of the vibrating probe.
Around the same time, a similar concept was
proposed
by Dr. Ian Newman in Australia.

These concepts were the basis to the development
of NMT
but this technology evolves every day
to fit the everchanging needs of its users.

Unlike technologies that provide scientists with
overall voltage, impedance, or current information,
NMT tells you which ions and/or molecules you are
measuring.
This provides you with the most direct and crucial
evidence
to the physiological functions.
NMT provides data on the fluxes of ions and
molecules.
This data shows information
on both direction and magnitude.
Additionally,
NMT is able to measure signals as low as
femtomoles
which makes it ideal for single cell research.
You may find yourself wondering
if NMT is 100% non-invasive?
The answer is both yes and no.
It will really depend on your sample.
For example,
when you work with a small Arabidopsis seedling
or the tail of a rat,
NMT is completely non-invasive.
But if you want to measure the epithilial cells of a
leaf
or the brain tissues of a rat,
you will first have to dissect
the tissues or cells from your sample.
But once it's in the liquid media,
your samples will NOT be touched again.

Due of the nature of NMT, it is capable of working
with single cells,
a layer of cells,
tissues,
organs,
and even small organisms
as long as they are in a liquid media.

Here's an example of how NMT
has been applied into real life research

This is an arabidopsis root that was tested using
YoungerUSA's commercialized IAA sensor.
With NMT we were able to measure the IAA fluxes
surrounding this root.
Results indicated a huge efflux of IAA
at the tip of the root.
But as you move to other regions of the root,
we see a minor influx of IAA.
With this information, scientists are able to study
the regulation of the growth of plants
which they were not able to study previously.
This makes NMT a very powerful tool for scientists.
Since the concept of NMT was introduced
in the early 1990s,
it has opened up a whole new dimension in science.
NMT is one of just a few technologies able to study
physiological functions of live samples in real time.
Because of this,
applications of NMT into biomedical research
have been growing exponentially in recent years.
We will cover these applications in a later video.
For more information,
please subscribe now or visit our website.
Thank you for watching, see you later!

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